Wider benefits of leukodepletion of blood products.

An animal model of allogeneic donor platelet refractoriness: the effect of the time of leukodepletion.

Approximately 50% of multi-transfused individuals become refractory to random donor platelets. Recent clinical data suggest that those patients receiving leukocyte-depleted blood products are less likely to become refractory to random donor platelets than recipients of non-leukocyte-depleted products. Leukocyte depletion can be performed immediately after collection of a unit of whole blood bef...

Alloimmunization and Refractoriness to Allogeneic Platelet Transfusions

F OUR YEARS AGO an editorial in Blood identified a number of issues concerning policy decision-making about the clinical use of leukodepleted cellular blood products to prevent HLA-alloimmunization and refractoriness to transfused allogeneic platelets.’ In that editorial, Schiffer concluded that it was premature to recommend platelet leukodepletion for routine use. The issues identified in that...

The leukodepletion of cellular blood products in the prevention of HLA-alloimmunization and refractoriness to allogeneic platelet transfusions.

Leukodepletion Filters for Prevention of Transfusion Transmission of Leishmania

BACKGROUND: Leishmania is an intracellular parasite of monocytes transmissible by transfusion. The feasibility of reducing Leishmania with leukodepletion filters was studied. At collection, infected blood contains the amastigote form of Leishmania within monocytes. Amastigotes cause the rupture of monocytes releasing free amastigotes that convert to promastigotes which exist extracellularly at ...

Growth enhancement of established tumors by allogeneic blood transfusion in experimental animals and its amelioration by leukodepletion: the importance of the timing of the leukodepletion.

We had reported previously (Blood 81:1880, 1993) that allogeneic blood transfusions (ABT) administered before the infusion of tumor cells in both inbred and outbred experimental animals promote tumor growth and that this effect can be ameliorated by leukodepletion. To better reproduce the human situation, we evaluated, in this present study, the effect of ABT in animals with established tumors ...